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HMGB1、VEGF-C在肺癌组织中的表达及临床意义 被引量：8

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摘要 采用免疫组织化学染色方法检测肺癌组织中高迁移率族蛋白1(HMGB1)及血管内皮生长因子C(VEGF-C)的表达。结果发现,非小细胞肺癌(NSCLC)组织HMGB1及VEGF-C阳性率明显高于癌旁组织(P<0.05)。HMGB1在肺鳞癌组织中阳性表达率明显低于腺癌组织,而其癌旁组织阳性表达率明显高于腺癌癌旁组织(P均<0.05)。肺鳞癌组织中VEGF-C阳性表达率明显低于腺癌组织(P<0.05);有淋巴结转移NSCLC组织HMGB1及VEGF-C阳性率明显高于无淋巴结转移NSCLC(P均<0.05);VEGF-C表达与HMGB1表达呈正相关(P<0.05)。认为HMGB1和VEGF-C的表达与肺癌组织病理类型和淋巴结转移相关,可作为肺癌转移、治疗和预后判断指标。
作者 徐圣葆 梅晓冬
机构地区 安徽医科大学附属省立医院
出处 《山东医药》 CAS 北大核心 2009年第12期50-51,共2页 Shandong Medical Journal
关键词 肺肿瘤 高迁移率族蛋白1 血管内皮生长因子C
分类号 R734.2 [医药卫生—肿瘤]
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参考文献7

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二级参考文献10

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共引文献8

同被引文献71

引证文献8

二级引证文献36

山东医药
2009年 第12期

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