丙泊酚对妇科腹腔镜手术气腹时血流动力学的影响

Influence of propofol on haemodynamics in gynecological patients undergoing laparoscopy opration

目的观察内泊酚对妇科腹腔镜手术气腹时血流动力学的影响。方法将ASAⅠ或Ⅱ级60例妇科腹腔镜手术患者随机分为丙泊酚组（P）和对照组（C）。以咪唑安定、芬太尼、维库溴铵、丙泊酚顺序静脉注射麻醉诱导，异氟醚维持麻醉。P组在气腹前5min注射丙泊酚，C组不予处理。分别监测干预（气腹前静注丙泊酚）前、干预后3min、置入腹腔镜时、气腹（5、10min）、停气腹前的动脉收缩压（SBP）和心率（HR）的变化。结果气腹后C组的SBP和HR显著升高（P〈0．01）；P组气腹后5、10min及停气腹前SBP明显低于C组（P〈0．01），C组气腹后5、10min及停气腹前的HR明显高于P组（P〈0．01）。结论丙泊酚能改善妇科腹腔镜手术气腹时血流动力学的变化。

Objective To observe the effects of propofol on haemodynamics in gynecological patients undergoing laparoscopy opration. Methods 60 female patients, ASA class Ⅰ or Ⅱ, undergoing laparoscopy opration under general anesthesia, were randomly divided into control group （C） and propofol group （P）.Anesthesia was induced by infusion of midazolam, fentany, vecuronium and propofol, After trachea intubation, anesthesia was maintained by isoflurane, group P was injected propofol, at 5min before pneumoperitoneum ,group C was injected nothing as the control. Observed SBP and HR at the time points. Results After pneumoperitoneum, SBP and HR were significantly increased in group C（P〈0.01）.Compared with group P and group C, there was significant change in SBP and HR after pneumoperitoneum（P〈 0.01）.Conclusion Propofol can change haemodynamics in gynecological patients undergoing laparoscopy opration.