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肾小球足细胞骨架结构的适应性应变 被引量：4

Adaptive Reaction of Actin Cytoskeleton in Podocyte Structure of Glomerulus
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摘要 肾小球足细胞肌动蛋白骨架是一个复杂的网络结构,其形态结构的稳定性与裂孔隔膜、足突顶端、足突基底等区域的相关蛋白分子密切相关,面对外力作用,在RhoA/Rho激酶信号通路、瞬时受体电位阳离子通道蛋白6(TRPC6)等参与下,足细胞骨架能在一定范围内进行适应性应变,以维护肾小球的正常滤过功能。 Actin cytoskeleton in podocyte is a complicated network structure,and the stability of this structure depend on many proteins which located in slit diaphragm,the apical membrane domain and the basal membrane domain with the stimulus of mechanical stress,the actin cytoskeleton can be adaptive regulated to maintain the normal function of glomerulus,and several signal pathways involve in the process,such as RhoA/Rho kinase signal pathway and TRPC6.
作者 康郁林 朱光华 何威逊
机构地区 上海交通大学医学院附属儿童医院肾脏风湿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2009年第5期383-385,共3页 Journal of Applied Clinical Pediatrics
关键词 足细胞骨架 裂孔隔膜 RhoA/Rho激酶信号通路 P38MAP激酶 actin cytoskeleton in podocyte slit diaphragm RhoA/Rho kinase signal pathway p38MAP kinase
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献19

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共引文献6

同被引文献44

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引证文献4

二级引证文献17

实用儿科临床杂志
2009年 第5期

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