p33ING1在结外鼻型NK／T细胞淋巴瘤中的表达

Expression of p33ING1 proteins in extranodal nasal type NK/T cell lymphoma

目的探讨抑癌基因p33ING1任结外鼻型NK／T细胞淋巴瘤（下称ENKL）中的表达情况，研究ENKL的发病机制，寻找有助于判断预后的分子标志物。方法用免疫组化方法检测p33ING1蛋白在37例ENKL和37例良性淋巴组织增生中的表达，统计各蛋白表达与临床特点及生存期的关系。结果37例良性淋巴组织增生p33ING1呈强阳性表达，在ENKL中的表达率约分别为67．57％（25／37），显著低于良性淋巴组织增生组（P〈0．01），p33ING1表达与LDH水平有关（P〈0．05）。结论p33ING1蛋白表达低下可促进ENKL的发生和发展。

Objective To study expressions of p33ING1 proteins in extranodal nasal type NK/T cell lymphoma（ENKL）. Methods p33ING1 were detected by immunohistochemistry in 37 cases of ENKL and 37 cases of benign lymphoid tissue proliferation. Results Expressions of p33ING1 and in ENKL were 67.57%, lower than that in benign lymphoid tissue proliferation. Low expression of p33ING1 in ENKL was correlation to patients＇ high level LDH. Conclusions Low or lost expression of p33ING1 may play on important role on the development and progression of ENKL.