摘要
为超过二十年，免疫学者一直在使用所谓的 Th1/Th2 范例解释大多数与适应免疫有关的现象。Th1/Th2 范例暗示了存在二不同，互相调整了， CD4+ T 助手子集：Th1 房间，涉及织物损坏的开车调停房间的有免疫力的回答和对细胞内部的寄生虫的战斗感染；并且调停的 Th2 房间 IgE 生产并且特别地涉及肠虫的感染的嗜曙红的发炎，过敏症和清理。设置的 T 助手，的第三个成员 IL-17-producing CD4+ T 房间，现在叫的 Th17 房间，最近被描述为做自己分内的事的一个不同的系有 Th1 或 Th2 房间的发展小径。Th17 子集被连接了到自体免疫的混乱，能在另外的煽动性的 cytokines 之中生产 IL-17， IL-17F 和 IL-21。有趣地，有，这被报导了不仅一在 Th1， Th2 和 Th17 受动器房间之中跨规定但是也在 Th17 和 T 的产生有两分规章的房间。因此， Treg 和 Th17 受动器房间以一种互相独占的方式产生，取决于他们是否面对加象 IL-6 那样的煽动性的 cytokines 的 TGF- 尾或 TGF- 尾被激活。这评论将在他们的发展和规定探讨 Th17 房间，和最近的进步的发现。
For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. The Thl/Th2 paradigm implied the existence of two different, mutu- ally regulated, CD4＋ T helper subsets： Thl cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particu- larly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4＋ T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Thl or Th2 cells. The Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Thl, Th2 and Th17 effector cells but there is also a di- chotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-β or TGF-β plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.
