期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TCRαβ T细胞CDR3谱系分析在移植免疫中的应用 被引量：1

原文传递
导出
摘要 分析T细胞CDR3区基因长度和序列(CDR3谱系分析)可确切了解T细胞亚家族的克隆扩增情况,筛选出与排斥反应、耐受状态的建立和移植并发症相关的克隆性T细胞。目前,CDR3谱系分析已应用于移植免疫研究,包括造血干细胞移植(hematopoietic stem cell transplantation,HSCT)和器官移植,成为检测受者特异T细胞克隆的一种有效工具。本综述主要介绍CDR3谱系分析在评价移植物抗宿主病(graft-versus-host disease,GVHD)、受者免疫重建和疾病诊断方面的作用。
作者 王梦川 罗微 马骊
机构地区 南方医科大学生物技术学院分子免疫学研究所
出处 《现代免疫学》 CAS CSCD 北大核心 2009年第2期169-172,共4页 Current Immunology
基金 教育部新世纪优秀人才支持计划(NCET-07-0410) 国家自然科学基金资助项目(30771952) 广东省自然科学基金资助项目(07117783)
关键词 T细胞受体 造血干细胞移植 移植物抗宿主病 CDR3谱系分析
分类号 R392.4 [医药卫生—免疫学]
  • 相关文献

参考文献20

  • 1Miqueu P, Guillet M, Degauque N, etal. Statistical analysis of CDR3 length distributions for the assessment of T and B cell repertoire biases[J]. Mol Immunol, 2007,44:1057- 1064.
  • 2Long SA, Khalili J, Ashe J, et al. Standardized analysis for the quantification of Vbeta CDR3 T-cell receptor diversity [J]. J Immunol Methods, 2006,317:100-113.
  • 3Ichiki Y, Bowlus CL, Shimoda S, et al. T cell immunity and graft-versus-host disease (GVHD) [ J ]. Autoimmun Rev, 2006,51:1-9.
  • 4Dirienzo CG, Murphy OF, Jones SC, et al, T-cell receptor Valpha spectra type analysis of a CD4-mediated T cell response against minor histoeompatibility antigens involved in severe graft-versus-host disease [J]. Biol Blood Marrow Transplant, 2006,12: 818-827.
  • 5Du JW, Gu JY, Liu J, et al. TCR spectratyping revealed T lymphocytes associated with graft versus-host disease after allogeneic hematopoietic stem cell transplantation[J]. Leuk Lymphoma, 2007,48:1618-1627.
  • 6Scheinberg P, Price DA, Ambrozak DR, et al. Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineering[J]. Exp Hematol, 2006,34 : 788-795.
  • 7Friedman TM, Filicko O'Hara J, Mookerjee B, et al. T cell repertoire complexity is conserved after LLME treatment of donor lymphocyte infusions[J]. Biol Blood Marrow Transplant, 2007,13:1439-1447.
  • 8Meyer RG, Britten CM, Wehler D, et al. Prophylactic transfer of CD8-depleted donor lymphocytes after T-cell-depleted reduced-intensity transplantation[J]. Blood, 2007,109:374-382.
  • 9Peggs KS, Verfuerth S, Pizzey A, et al. Reconstitution of T- cell repertoire after autologous stem cell transplantation: influence of CD,34 selection and cytomegalovirus infection. [J]. Biol Blood Marrow Transplant, 2003,9:198-205.
  • 10Mackinnon S, Thomson K, Verfuerth S, et al. Adoptive cellular therapy for cytomegalovirus infection following allogeneic stem cell transplantation using virus-specific T cells [J]. Blood Cells Mol Dis, 2008,40:63-67.

同被引文献12

  • 1Thedrez A, Sabourin C, Gertner J, et al. Self/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue [J]? Immunol Rev, 2007, 215: 123- 135.
  • 2Shin S, EI-Diwany R, Schaffert S, etal. Antigen recognition determinants of gammadelta T ceil receptors [J]. Science, 2005, 308:209 -210.
  • 3Chien YH, Konigshofer Y. Antigen recognition by gammadelta T cells [J]. Immunol Rev, 2007, 215: 46-58.
  • 4Hochberg MC. Updating the American College of Rheuma tology revised criteria for the classification of systemic lupus erythematosus [J]. Arthritis Rheum, 1997, 40: 1725.
  • 5Shen N, Tsao BP. Current advances in the human lupus genetics[J]. Curr Rheumatol Rep, 2004,6 : 391-398.
  • 6Hirsh MI, Junger WG. Roles of heat shock proteins and gamma delta T cells in inflammation[J]. Am J Respir Cell MolBiol, 2008, 39:509 -513.
  • 7Flament C, Benmerah A, Bonneville M, et al. Human TCR- gamma/delta alloreactive response to HLA DR molecules.Comparison with response of TCR-alpha/beta[J]. J Immunol,1994, 153:2890-2904.
  • 8Xiong N, Zhang L, Kang C, et al. Gene placement and competition control T cell receptor gamma variable region gene rearrangement [J]. J Exp Med, 2008, 205:929-938.
  • 9Hviid L, Akanmori BD, Loizon S, et al. High frequency of circulating gamma delta T cells with dominance of the v(delta) 1 subset in a healthy population [J]. Int Immunol, 2000, 12: 797-805.
  • 10Evans PS, Enders PJ, Yin C, et al. In vitro stimulation with a non peptidic alkylphosphate expands cells expressing Vgamma2-Jgammal. 2/Vdelta2 T-cell receptors [J]. Immunology, 2001, 104:19- 27.

引证文献1

二级引证文献1

现代免疫学
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部