盐酸米诺环素对牙周袋内硫化物水平的影响

The effect of local administration of minocycline gel on sulfide level in periodontal pockets after scaling and root planing

目的评价口臭的牙周炎患者局部应用盐酸米诺环素软膏对牙周袋内硫化物水平的影响。方法对15例以口臭为主诉的慢性牙周炎患者采用分口(split-mouth)设计,同一患者的一侧半口随机采用刮治和根面平整术(scaling and root planing,SRP),另一侧采用SRP辅助用盐酸米诺环素软膏治疗。基线、治疗后6周、3个月时检查牙周袋内硫化物(sulfide in periodontal pockets,pS)水平、探诊深度(probing depth,PD)、临床附着水平(clinical attachment level,CAL)、出血指数(bleeding index,BI)、菌斑指数(plaque index,PLI),在基线、治疗后6周刚果红涂片进行龈下微生物计数。结果在治疗后6周、3个月,SRP+米诺环素组与单纯SRP组的各项临床指标均较治疗前明显改善(P<0.05);比较两组间pS值、PD、CAL、PLI、BI、龈下螺旋体比例,差异均无统计学意义。结论对于口臭的牙周炎的患者,盐酸米诺环素辅助SRP较单纯的SRP并未显示很大的优势;牙周治疗可持续3个月降低袋内硫化物水平。

Objective To evaluate the effect of subgingival delivery of 2% minoeycline hydrochloride gel on sulfide level in periodontal pockets after sealing and root planing （SRP） in periodontal patients with halitosis. Methods Fifteen mild or moderate periodontitis patients with halitosis were enrolled. Split - mouth design was used that SRP or SRP ＋ minocycline was randomly applied for the right or left half of the month. The sulfide level in periodontal pocket, probing depth （PD）, clinical attachment level （CAL）, bleeding index （BI）, plaque index （PLI） were recorded before and after treatment for 6 weeks and 3 months. The percentages of spirochetes were evaluated by Congo red smear. Results All the sulfide, PD, CAL, BI, PLI, and spirochetes were decreased significantly after SRP or SRP ＋ minocycline treatment（ P 〈 0.05 ）. However no significant differences were observed between SRP or SRP ＋ minocyeline treatment after treated for 6 weeks and 3 months. Conclusion The results demonstrated that subgingival administration of minocyeline gel after SRP did not show more favorable periodontal healing results compared with SRP treatment alone. The sulfide level in pocket was reduced signifieantly for at least 3 months by both treatments.