药物在口腔黏膜中的渗透性研究

Drug permeability through buccal mucosa

目的:研究药物的理化性质对口腔黏膜渗透性的影响。方法:选取苯甲酸和咖啡因及氢化可的松为模型药物,以离体猪颊黏膜作为动物模型,测定渗透系数。结果:苯甲酸和咖啡因及氢化可的松透过口腔黏膜的渗透系数分别为:(1.01×10-4±1.64×10-5)cm·s-1,(2.75×10-5±1.79×10-6)cm·s-1和(2.49×10-5±6.32×10-6)cm·s-1。结论:药物的口腔黏膜渗透性大于人皮渗透性。对于不同的药物,其增大倍数可能相差很大,苯甲酸和咖啡因及氢化可的松通过口腔黏膜的渗透系数分别是通过人皮的14倍和989倍及389倍。

Objective： To investigate the effects of physicochemical properties of drug on its permeability through buccal mucosa. Methods： Benzoic acid, caffeine and hydrocortisone were selected as model drugs and their permeability coefficients through isolated porcine buccal mucosa were determined. Results： The permeability coefficients of benzoic acid, caffeine and hydrocortisone through isolated porcine buccal mucosa were （1.01 × 10^-4± 1.64 × 10^-5）cm · s^-1, （2.75×10^-5±1.79×10^-6）cm · s^-1 and （2.49×10^-5±6.32×10^-6）cm · s^-1,which were 14,989 and 389 times as those through human skin,respectively. Conclusion： The permeability of drugs through buccal mucosa seems to be much better than that through human skin.