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HBx对感染细胞信号通路的调控及其与肝癌的发生 被引量：1

Modulation of Signal Transduction Pathways in Infected Cells by Hepatitis B Virus X Protein and its Role in Development of Hepatocellular Carcinoma
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摘要 乙型肝炎病毒（HBV）X基因及其编码的多功能蛋白HBx是乙型肝炎病毒基因转录所必需的作用因子。同时，HBx通过与宿主功能蛋白直接或间接地相互作用而调节多种蛋白的功能，参与调控多条细胞信号通路转导，激活多种转录因子，在肝细胞抗凋亡和引发肝癌的过程中起重要作用。 Hepatisis B virus and its multifunctional protein HBx are essential for virus genetic transcription. HBx can directly or indirectly interact with host proteins, activates different transcription factors, and influences a variety of signal transduction pathways in infected cells. In most cases, this small viral protein favors cell survival and probably initiates hepatocarcinogenesis.
作者 周玉 沈关心
机构地区 华中科技大学同济医学院基础医学院免疫学系
出处 《医学分子生物学杂志》 CAS CSCD 2009年第2期181-184,共4页 Journal of Medical Molecular Biology
基金 国家重点基础研究发展规划项目（973计划）（No.2007CB51290）
关键词 HBX蛋白 信号通路 肝癌 HBx protein signal transduction pathway hepatoeellular carcinoma
分类号 R373.2 [医药卫生—病原生物学]
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参考文献22

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同被引文献19

  • 1汤蕾,张吉翔,熊瑛.人着色性干皮病D组基因的克隆及其真核表达[J].生物医学工程学杂志,2008,25(3):668-672. 被引量：12
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医学分子生物学杂志
2009年 第2期

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