子宫内膜异位症患者血清、腹腔液中Ang-2和ENS的表达变化及意义被引量：2

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摘要选择卵巢子宫内膜异位症(EMs)患者30例(研究组)、子宫肌瘤及输卵管绝育术(无子宫内膜病变)30例(对照组),采用酶联免疫吸附试验检测两组患者血清及腹腔液中的血管生成素-2(Ang-2)及内皮抑素(ENS)。结果显示,研究组血清、腹腔液的Ang-2分别为(98.36±17.92)、(114.74±40.73)ng/ml,对照组分别为(33.91±7.17)、(37.66±6.09)ng/ml,两组相比,P均<0.05;研究组血清、腹腔液的ENS分别为(7.50±1.91)、(5.31±0.91)pg/ml,对照组分别为(4.14±0.73)、(3.27±0.80)pg/ml,两组相比,P均<0.05;研究组血清与腹腔液Ang-2含量呈正相关(r=0.75,P<0.05),与ENS含量也呈正相关(r=0.63,P<0.05)。认为Ang-2和ENS参与了EMs的血管生成过程,二者在血清中的高表达有望作为EMs诊断及治疗随访的指标之一,腹腔微环境改变参与调节EMs异位病灶的生长和进展。

作者范俊董文韬栾少红孙宝治王纯

机构地区青岛市市立医疗集团莱西市人民医院

出处《山东医药》 CAS 北大核心 2008年第33期47-48,共2页 Shandong Medical Journal

关键词子宫内膜异位症血管生成素-2 内皮抑素

分类号 R711.71 [医药卫生—妇产科学]

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