HCC患者血清AFP、ICAM-1、乙肝标志物的表达变化及意义

Expression and significance of serum AFP,ICAM-1 and HBV markers in patients with hepatocellular carcinoma

目的探讨肝细胞癌(HCC)患者血清甲胎蛋白(AFP)、细胞间黏附分子(ICAM)-1与乙型肝炎病毒(HBV)感染的关系。方法采用化学发光免疫分析和ELISA法分别检测120例HCC患者(HCC组)、40例健康查体者(对照组)血清AFP、ICAM-1水平;采用ELISA法检测其五项HBV血清标志物水平。结果HCC组中107例HBV五项标志阳性,HBV总感染率为89.2%,以HBsAg、抗-HBe和抗-HBc-IgG阳性模式多见,占44.9%。HCC组AFP、ICAM-1水平明显高于对照组(P均<0.01)。AFP与ICAM-1水平呈正相关(r=0.627,P=0.0081)。结论HBV感染是HCC发生的一个重要的危险因素,AFP、ICAM-1联合检测有助于HCC的早期诊断。

Objective To explore the relationship between hepatocellular arcinoma （HCC） patients with serum alpha fetoprotein（AFP）, ICAM-1 and hepatitis B virus （HBV） infection. Methods Blood serum AFP, ICAM-1 and five HBV markers from 120 HCC （HCC group） and 40 healthy controls （control group） were separately detected with chemilum inescence immunoassay and ELISA. Results In HCC group, 107 patients＇five HBV markers were positive. The total HBV infection rate was 89.2%. The infection models of HBV serum marker in HCC patients was mostly HBsAg, anti-HBe and anti-HBc-IgG positive models, which accounted for 44.9%. The AFP and ICAM-1 levels in HCC patients were significantly higher than control group（P〈0.01） and level was positively correlated（r =0.627, P=0.0081）. Conclusions HBV in- fection is an important danger factor in the genesis of HCC. The AFP and ICAM-1 combined detection of conducive early conclusion in HCC.