期刊文献+

宫颈癌及癌前病变组织中CD_(24)mRNA的表达及意义 被引量:1

下载PDF
导出
摘要 采用RT-PCR技术检测40例宫颈癌、30例宫颈癌前病变及30例正常宫颈组织中的CD24mRNA。结果显示,CD24mRNA在正常宫颈组织中不表达,在宫颈癌前病变和宫颈癌组织中的表达水平(相对值)分别为0.113±0.059、0.302±0.053,两者相比,P<0.05;CD24mRNA表达与宫颈癌组织学分级有密切关系(P<0.05),而与临床分期无关(P>0.05)。认为在正常宫颈到宫颈癌的演变过程中,CD24mRNA的表达逐渐呈上升趋势,可作为预测宫颈肿瘤恶变的生物学指标之一。
出处 《山东医药》 CAS 北大核心 2008年第47期81-82,共2页 Shandong Medical Journal
  • 相关文献

参考文献4

  • 1庄建良,苏子剑,许荣誉.CD24与肿瘤侵袭转移的关系[J].国际病理科学与临床杂志,2006,26(5):387-390. 被引量:13
  • 2Ye P, Nadkarni MA, Humter N. Regulation of E-cadherin and TGF- beta 3 expression by CD24 in cultured oral epithelial cells [J]. Biochemical and Biophysical Research Communications,2006,349 ( 1 ) : 229-235.
  • 3李福敏,张蔚,张孝斌,黄晶,李丹.槲皮素对HeLa细胞中HPV18 E7、P16 mRNA表达的影响[J].武汉大学学报(医学版),2008,29(2):181-185. 被引量:3
  • 4Petra B, Natatascha C. CD24 expression causes the cquisition of multiple cellular properties associated with tumoe growth and metasis [ J ]. Cancer Res ,2005,65 (23) : 10783-10793.

二级参考文献39

  • 1赵富玺,郭俊成,崔克,熊思东.cyclin E、p16ink4、ki67在宫颈脱落细胞中的表达及其与HPV_(16/18)感染的相关性[J].中华实验和临床病毒学杂志,2005,19(2):138-141. 被引量:10
  • 2Kay R, Rosten P M, Humphries R K. CD24, a signal transducer modulating B cell activation responses, is a very short peptide with a glycosyl phosphatidylinositol membrane anchor[J].J Immunol,1991,147(4) :1412-1416.
  • 3Kristiansen G, Denkert C, Schluns K, et al. CD24 is expressed in ovarian cancer and is a new independent prognostic marker of patient survival[ J ]. Am J Pathol,2002,161 (4) : 1215-1221.
  • 4Choi Y L, Kim S H, Shin Y K, et al. Cytoplasmic CD24 expression in advanced ovarian serous borderline tumors [ J ]. Gynecol Oncol, 2005,97 (2) :379-386.
  • 5Surowiak P, Matema V, Kaplenko I, et al. Unfavorable prognostic value of CD24 expression in sections from primary and relapsed ovarian cancer tissue [J]. Int J Gynecol Cancer, 2006,16 ( 2 ) : 515 -521.
  • 6Wei J J, Chiriboga L, Mittal K, et al. Expression profile of the tumorigenic factors associated with tumor size and sex steroid hormone status in uterine leiomyomata [ J ]. Fertil Steril, 2005,84 (2) :474 -484.
  • 7Nestl A, Von Stein O D, Zatloukal K , et al. Gene expression patterns associated with the metastatic phenotype in rodent and human tumors [ J ]. Cancer Res ,2001,61 (4) : 1569-1577.
  • 8Kristiansen G, Winzer K J, Mayordomo E, et al. CD24 expression is a new prognostic marker in breast cancer[J].Clin Cancer Res,2003,9( 13 ) :4906-4913.
  • 9Surowiak P, Materna V, Gyorffy B, et al. Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers [ J 1. Br J Cancer, 2006,95 ( 3 ) :339-346.
  • 10Al-Hajj M, Wicha M S, Benito-Hemandez A, et al. Prospective identification of tumorigenic breast cancer cells[ J]. Proc Natl Acad Sci USA,2003,100( 7 ) :3983-3988.

共引文献14

同被引文献22

  • 1乐杰.妇产科学[M].第7版.北京:人民卫生出版社,2007:6
  • 2Rajasagi M, Vitacolonna M, Benjak B, et al. C D44 promotes progenitor homing into the thymus and T cell maturation [ J ]. J Leukoe Biol, 2009,85 (2) :251 -261.
  • 3Canavan TP, Doshi NR. Cervical cancer [ J ]. Am Fam Physician, 2000,61 (5) : 1369 - 1376.
  • 4Pectasides D, Kamposioras K, Papaxoinis G, et al. Chemotherapy for recun'ent cervical cancer[ J ]. Cancer Treat Rev,2008,34 (7) :603 - 613.
  • 5Choi YL, Lee SH, Kwon GY, et al. Overexpression of CD24 : associa- tion with invasiveness in urothelial carcinoma of the bladder [ J ]. Arch Pathol Lab Med,2007,131 (2) :275 -281.
  • 6Kristiansen G, Winzer K J, Mayordomo E,et a|. CD24 e~pression is a new prognostic marker in breast cancer[ J]. Clin Cancer Res,2003, 9(13) :4906 -4913.
  • 7Sano A, Kato H, Sakurai S, et al. CD24 expression is a novel prog- nostic factor in esophageal squamous cell carcinoma [ J ]. Ann Surg Oneo1,2009,16 (2) :506 - 514.
  • 8Wei HJ, Yin T, Zhn Z, et al. Expression of CD44, CD24 and ESA in pancreatic adenocarcinoma cell lines varies with local microenvi- romnent[ J ]. Hepatobiliary Pancreat Dis Int, 2011, 10(4) :428 - 434.
  • 9Lee HJ,Kim DI,Kwak C,et al. Expression of CD24 in clear tell re- nal tell carcinoma and its prognostic significance [ J ]. Urology, 2008,72 ( 3 ) :603 - 607.
  • 10Weiehert W, Denkert C, Burkhardt M, et al. Cytoplasmic CD24 expression in eolorettal cancer independently ton'elates with short- ened patient survivall J ]. Clin Cancer Res, 2005,11 ( 18 ) :6574 - 6581.

引证文献1

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部