期刊文献+

类风湿关节炎关节滑膜细胞中IL-18表达及意义 被引量:3

下载PDF
导出
摘要 取类风湿关节炎(RA)患者的关节滑膜40份(RA组)及外伤后患者的关节滑膜40份(对照组),用胶原酶消化培养法培养至3-8代,用免疫组化法检测滑膜细胞IL-18表达,用酶联免疫吸附检测细胞培养上清液中IL-18水平。结果RA组滑膜细胞及上清液中IL-18分泌量明显高与对照组(P〈0.05)。认为IL-18高表达参与RA发病,可作为临床治疗的靶点之一。
作者 曲瑾
出处 《山东医药》 CAS 北大核心 2008年第48期99-100,共2页 Shandong Medical Journal
  • 相关文献

参考文献2

  • 1Pay S, Erdem H, Pekel A, et al. Synovial proinflammatory cytokines and their correlation with matrix metalloproteinase-3 expression in Behcetg disease. Does interleukin-lbeta play a major role in Behcet's synovitis? [J]. Rheumatol,2006,26(7) :608-613.
  • 2Petrovic-Rackov L, Pejnovic N. Clinical significance of IL-18, IL- 15, IL-12 and TNF-alpha measurement in rheumatoid arthritis [ J]. Clin Rheumatol, 2006,25(4) :448-52.

同被引文献48

  • 1王叶萍,姚航平.类风湿性关节炎患者血清和滑液IL-18及IL-18结合蛋白的水平及意义[J].检验医学,2004,19(6):518-520. 被引量:9
  • 2李强,黄宪章,丁海明,庄俊华.外周血白细胞介素-18与类风湿性关节炎相关性研究[J].实用医学杂志,2007,23(8):1143-1144. 被引量:8
  • 3Klareskog L, Catrina AI, Paget S, et al. Rheumatoid arthritis [J]. Lancet, 2009, 373(9664):659- 672.
  • 4Shao XT, Feng L, Gu LJ, et al. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis[J]. Clin Exp Med, 2009, 9(3):215-221.
  • 5Boraschi D, Dinarello CA. IL-18 in autoimmunity: review[J]. Eur Cytokine Netw, 2006, 17(4):224 -252.
  • 6Joosten LA, Radstake TR, Lubberts E, et al. Association of interleukin -18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis [J].Arthritis Rheum, 2003, 48(2) :339-347.
  • 7Bresnihan B, Roux Lombard P, Murphy E, et al. Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis[J]. Ann Rheum Dis, 2002, 61(8):726-729.
  • 8Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis [J]. Arthritis Rheum, 2008, 58(10):2958-2967.
  • 9Bokarewa M, Hultgren O. Is interleukin-18 useful for monitoring rheumatoid arthritis [J]? Scand J Rheumatol, 2005, 34(6) :433-436.
  • 10Muhl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory interve- ntion[J]. Eur J Pharmaeol, 2004, 500(1):67 -71.

引证文献3

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部