舌鳞癌中微淋巴管密度与淋巴结转移之间的关系

Lymphatic microvessel density in tongue squamous cell carcinoma correlate with lymphatic metastasis

目的分析舌鳞癌组织中微淋巴管密度（LMVD）与淋巴结转移之间的关系。探讨微淋巴管密度在预测舌鳞癌淋巴结转移中的作用。方法应用免疫组化方法，在69例舌鳞癌中用淋巴管内皮细胞特异性抗体D2—40标记淋巴管，计数肿瘤LMVD，结合临床病理因素进行分析。结果舌鳞癌中微淋巴管密度为33．24±0．09，明显高于正常黏膜微淋巴管密度（6．23±0．23）（P〈0．01）；淋巴结转移组微淋巴管密度为38．15±0．35．明显高于非转移组（27．56±0．05）（P〈0．05）。结论LMVD密度与舌鳞癌淋巴结转移呈正相关，其中舌鳞癌微淋巴管密度测定对预测其淋巴结转移可能具有重要意义。

Objective To analyse the correlation of the density of lymphatic microvessel with lymphatic metastasis in the tongue squamous cell carcinoma. To discuss the effect of determination of the density of lymphatic microvessel in evaluation lymphatic metastasis of the tongue squamous cell carcinoma. Methods Making use of immunohistochemistry to research, the lymphatic microvessel was marked with D2 - 40. The density of lymphatic microvessel was counted. Results LMVD value （33.24 ± 0.09） in the tongue squamous cell carcinoma was higher than in the normal tongue mucosa （6.23 ± 0.23 ）, P 〈 0. 05. LMVD value in lymphatic metastasis （38.15 ± 0.35 ） group was higher than in the non - lymphatic metastasis group（27.56 ± 0.05 ）, P 〈 0.05. Conclusions The density of lymphatic microvessel is associated with the lymphatic metastasis of the tongue squamous cell carcinoma. It has sense to determin the density of lymphatic microvessel in evaluation lymphatic metastasis of the tongue squamous cell carcinoma.