凋亡抑制蛋白Livin在结直肠癌中的表达及意义

The Expression of Livin in Colorectal Carcinoma and its Significance

探讨凋亡抑制蛋白Livin在结直肠癌组织中的表达及意义。采用免疫组化Elivision法检测68例结直肠癌组织、20例正常结直肠组织中Livin的表达情况。结果显示，20例正常结直肠组织无Livin表达，Livin在结直肠癌组织中表达阳性率47．1％，Livin的表达与患者性别、年龄、肿瘤大小及侵犯深度无关，与分化程度、淋巴结转移有关。结果表明，Livin蛋白与结直肠癌的发生发展有关，并可能成为结直肠癌基因治疗的新靶点。

The objective of this study is to discuss the expression of livin in eoloreetal carcinoma and its significance. The expression of Livin in colorectal carcinoma of 68 patients and in normal coloreetal tissues of 20 cases was measured with irnmunohistochemical Elivision method, the impact of which was discussed. As results, there was no Livin expression in the normal colorectal tissues of the 20 persons, the positive rate of Livin expression in colorectal carcinoma was 47.1%（32/68）,and Livin expression was not correlated with sex,age,tumor size and infiltration degree,while Livin expression was correlated with differentiation degree and lymph node metastasis. It is concluded that Livin is correlated with the occurrence and development of colorectal carcinoma and may become a new target of gene thereapy for colorectal carcinoma.