羧甲基壳聚糖包衣尼莫地平纳米脂质体药效学研究

Effects of Carboxymethyl Chitosan-coated Nimodipine Nanoliposomes on Cerebral Anoxia and Cerebral Embolism in Mice

目的:研究羧甲基壳聚糖(CMC)包衣尼莫地平(NMD)纳米脂质体对小鼠脑缺氧及脑栓塞的影响。方法:采用亚硝酸钠所致小鼠脑缺氧实验以及诱导剂致小鼠脑栓塞实验,观察CMC包衣NMD纳米脂质体对小鼠脑缺氧及脑栓塞的影响,并与市售NMD注射液,普通NMD脂质体,CMC包衣NMD脂质体,NMD纳米脂质体进行比较。结果:CMC包衣NMD纳米脂质体能显著延长小鼠亚硝酸钠中毒后的存活时间,提高小鼠对抗脑栓塞的能力。结论:CMC包衣NMD纳米脂质体对小鼠脑缺氧以及脑栓塞有明显的预防保护作用。

Objective： To study the effects of carboxymethyl chitosan （CMC） -coated nimodipine （NMD） nanoliposomes on cerebral anoxia and cerebral embolism in mice. Method： Effects of CMC-coated NMD nanoliposomes on the survival time of cerebral anoxia in mice induced by NaNO2 , as well as the performance of cerebral embolism in mice after i.v. revulsant were observed, compared with marketed NMD injection, common NMD liposomes, CMC-coated NMD liposomes, non-coated NMD nanoliposomes. Result： CMC-coated NMD nanoliposomes had significant effects on prolonging the survival time of cerebral anoxia induced by NANO2 and enhanced the ability to oppose the cerebral embolism in mice. Conclusion： CMC-coated NMD nanoliposomes had promising preventative effects on cerebral anoxia and cerebral embolism in mice.