癌症患者血浆细胞因子水平的变化

STUDY ON THE LEVELS OF INTERLEUKIN 1、2、6 AND THE CONTENTS OF TUMOR NECROSIS FACTOR IN THE PATIENTS WITH CANCER

应用同位素掺入法及酶联法检测癌症患者血浆白细胞介素１、２、６（ＩＬ１、２、６）活性、肿瘤坏死因子（ＴＮＦ）含量。结果表明：癌症患者血浆ＩＬ１、ＩＬ２、ＩＬ６活性均显著低于对照组，而ＴＮＦ含量却显著高于对照组。提示细胞因子水平的异常可能在肿瘤发生过程中起重要作用。

Interleukin 1 (IL 1), interleukin 2(IL 2) and interleukin 6(IL 6) activities and tumor necrosis factor (TNF) contents in plasma from patients with different sites of cancers as well as controls using bioassay technique were studied. The results showed that the levels of IL 1,IL 2,IL 6 s from patients with different sites of cancer were decreased remarkably in comparision with controls and the contents of TNF from patients with different sites of cancers increased significantly. But the difference between different sites of cancer was not statistically significant. The data suggest that the variations in the contents of TNF and the levels of interleukins may be related to the development of these caner patients.