摘要
通过犬胆道梗阻模型，动态观察了胆道梗阻后不同时相肝组织内超氧化物歧化酶（ＳＯＤ）及丙二醛（ＭＤＡ）含量变化。结果发现：犬胆道梗阻后２周其肝组织ＭＤＡ含量较对照组明显升高（Ｐ＜０．０１），梗阻后３周ＳＯＤ含量亦有显著下降（Ｐ＜０．０５），且二者变化随着梗阻时间的延长而加重。表明胆道梗阻后肝脏对自由基的清除能力下降，脂质过氧化反应增强，可能是胆道梗阻导致肝损伤的原因之一。
Through dog models of common bile duct obstruction (BDO), the contents of liver superoxide dismutase (SOD) and malondialdehyde(MDA) were measured 2,3,4 and 5 weeks after BDO. Results indicated that the hepatic MDA content was increased 2 weeks after BDO as compared with control group ( P <0.01), the hepatic SOD content was decreased 3 weeks after BDO ( P <0.05). When bile duct obstructing, these changed were more serious. The results suggest that liver has little ability to eliminate the superoxide free radicals after BDO, whereas the lipid peroxidation products increase. It may be one of the mechanisms of liver damage after BDO.
出处
《中国普外基础与临床杂志》
CAS
1998年第3期148-149,共2页
Chinese Journal of Bases and Clinics In General Surgery
关键词
胆道梗阻
超氧化物歧化酶
丙二醛
Bile duct disease Liver Superoxide dismutase Malondialdehyde
