部分血浆凝血因子活性测定在急性冠脉综合征中的应用价值

Implications of partial plasma coagulation factor activity in acute coronary syndrome

目的观察急性冠脉综合征(ACS)患者部分凝血因子活性水平,探讨其在ACS发病中的意义。方法测定100例急性心肌梗死(AMI)和69例不稳定性心绞痛(UAP)患者急性期凝血因子Ⅴ、Ⅶ、Ⅷ、Ⅹ、Ⅺ活性(FⅤ:C、FⅦ:C、FⅧ:C、FⅩ:C、FⅪ:C),并与120例稳定性心绞痛(SAP)患者和80例健康对照组进行比较,分析这些因子活性水平与AMl和UAP急性期的关系。结果 AMI和UAP患者急性期FⅤ:C、FⅦ:C、FⅧ:C、FⅩ:C、FⅪ:C水平明显高于SAP组和健康对照组(P<0.05));SAP组和健康对照组比较差异无统计学意义(P>0.05)。结论 ACS患者急性期FⅤ:C、FⅦ:C、FⅧ:C、FⅩ:C、FⅪ:C水平明显升高,存在高凝状态。

Objective To investigate the activity of partial plasma coagulation factor activity and its clinical Significance in occurrence of acute coronary syndrome（ACS）. Methods The activities of coagulation factors（FⅤ：C, FⅦ ：C, FⅧ ：C, FⅩ：C and FⅪ ：C） were measured in 100 patients with acute myocardial infarction（AMI group） and 69 patients with unstable angina pectoris in acute stage（UAP group）, the results were compared with those of 120 cases of stable angina pectoris（SAP group） and 80 healthy controls（healthy control group）. The relationship was analyzed between activities of coagulation factors and AMI as well as acute stage UAP. Results The patients with acute myocardial infarction and unstable angina pectoris in acute phase had significantly higher plasma FⅤ ：C, FⅦ ：C, FⅧ ： C, FⅩ：C and FⅪ ：C compared with those of healthy and SAP subjects（P〈0.05）; there were no significant differences of the above activities between SAP group and healthy control group（P〉0.05）. Conclusion Significantly higher activation of FⅤ ：C, FⅦ ：C, FⅧ ： C, FⅩ：C and FⅪ ：C and a hypercoagutabale state exist in acute coronary syndrome（ACS） patients in acute stage.