生物阻抗技术评价多潘立酮对功能性消化不良胃动力的影响

Effects of domperidone on bio-impedance gastric motility of patient with functional dyspepsia.

目的研究多潘立酮对功能性消化不良(functional dyspepsia,FD)患者胃动力的影响。方法应用胃动力检测系统检测2007年6月至2008年2月重庆医科大学附属第一医院消化门诊30例FD患者餐后胃动力,同步提取胃阻抗信号和胃电信号,并对FD患者进行症状评分,多潘立酮10 mg每日3次治疗1周后,复查餐后胃动力并再次症状评分。结果经多潘立酮治疗后FD患者腹胀、腹痛、早饱、嗳气症状积分明显下降(P<0.05),餐后不适综合征(PDS)组症状改善较明显(P<0.05)。胃电主功率百分比治疗后[(58.03±8.05)%]较治疗前[(52.07±7.01)%]有显著提高(P<0.05)。治疗前,PDS组和上腹疼痛综合征(EPS)组主功率百分比差异无统计学意义(P>0.05);治疗后,PDS组主功率百分比[(46.50±4.08)%]显著高于EPS组[(41.99±3.10)%](P<0.01);PDS和EPS两组各频段功率百分比治疗前后差异均无统计学意义(P>0.05)。结论多潘立酮可改善FD患者的临床症状,恢复异常的胃电活动,阻抗胃动力紊乱并未完全恢复正常;经多潘立酮治疗后PDS组较EPS组阻抗胃动力紊乱改善较明显。

Objective To investigate the effects on patients of functional dyspepsia （FD） after treatment with domperidone. Methods 30 patients with functional dyspesia according to Rome Ⅲ were collected. The impedance signal and electrical signal were collected at the same time. Symptoms of 30 patients with FD were scored before and after treatment with domperidone 10 mg tid for 1 week. The gastric motility was tested repeatedly for comparison. Results Domperidone can significantly improve symptom scores of abdominal distention, abdominal pain, early satiety and belching（ P 〈 0. 05 ）. The patients with postprandial distress syndrome（PDS） improved significantly（P 〈 0.05）. The percentage of the power of dominant frequency of electrogastrogram before and after treatment were （52. 07±7.01 ）% and （58.03±8.05）% ,the difference was significant（ P 〈 0.05 ）. There was no difference in the percentage of the power of the dominant frequency of impedance gastrogram with PDS and EPS patients before treatment （ P 〉0.05 ） ; after Domperidone treatment, that was （46. 50±4. 08）% for PDS patients and （41.99±3. 10）% for EPS patients,the difference was significant（P 〈0. 01 ） ; the percentage of the power of the whole frequency range had no change in both PDS and EPS groups （ P 〉 0.05 ）. Conclusion Domperidone can relieve clinical symptom,improve electrical signal, but not impedance gastric motility. The impedance gastric motility of PDS patients improved significantly after treatment with Domperidone when compared with EPS patients.