免疫反应与慢性阻塞性肺疾病被引量：3

Immune response and chronic obstructive pulmonary disease.

导出

摘要慢性阻塞性肺部疾病(COPD)是一种以T淋巴细胞浸润为主的慢性炎症性疾病,而T淋巴细胞与免疫应答有关。了解免疫反应在COPD患者肺组织的变化特点,有利于了解免疫反应在COPD中所发挥的作用机制,以便进一步认识和治疗COPD。 Chronic obstructive pulmonary disease（COPD） is a chronic inflammatory disease characterized by infiltration of T-lymphocytes, which plays a key role in the immune response of human. Exploration on the characters of immune response in the pathologic process related to COPD may be useful to explore the mechenism of immunity response in COPD patients, thus, contrubute to improve the knowledge of COPD and investigating new avenues of treatment.

作者万鹏钟小宁

机构地区广西医科大学第一附属医院呼吸内科

出处《中国实用内科杂志》 CAS CSCD 北大核心 2009年第4期371-373,共3页 Chinese Journal of Practical Internal Medicine

基金国家自然科学基金项目(30860106)

关键词慢性阻塞性肺部疾病免疫反应 T淋巴细胞 chronic obstructive pulmonary disease immunity T-lymphocytes

分类号 R5 [医药卫生—内科学]

引文网络
相关文献

参考文献19

1GOLD Executive Committee. Methodology and summary of new recommendations global strategy for diagnosis, management and prevention of COPD: 2008 update [ DB/DL ]. www. goldcopd.com.
2Peinado VI, Barbera JA, Abate P, et al. Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease [J]. Am J Respir Crit Care Med, 1999, 159 : 1605 - 1611.
3Baraldo S,Saetta M. To reg or not to reg: that is the question in COPD [ J ]. Eur Respir J ,2008,31:486 -488.
4Lee SH, Goswami S, Grudo A, et al. Antielastin auto-immunity in tobacco smoking-induced emphysema [ J ]. Nat Med, 2007, 13 :567 -569.
5钟小宁,郭韶梅.慢性支气管炎与肺气肿大鼠肺血管炎症的实验研究[J].中华结核和呼吸杂志,2006,29(7):435-439. 被引量：22
6Saetta M, Mafiani M, Panina-Bordignon P, et al. Increased expression of the ehemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstruetive pulmonary disease[ J]. Am J Respir Crit Care Med ,2002,165 (10) :1404 - 1409.
7Tsoumakidou M, Demedts IK, Brusselle GG, et al. Dendritic Cells in Chronic Obstructive Pulmonary Disease. New Players in an Old Game [ J ]. Am J Respir Crit Care Med,2008,177 : 1180 - 1186.
8Miler LA, Huest SD, Coffman RL, et al. Airway generatio-specific different in the spatial distribution of immune ceils and ctokines in allergic-challenged rhesus monkeys [ J ]. Clin Exp Allergy,2005, 35:894 - 906.
9Maeno T, Houghton AM, Quintero PA, et al. CD8 T ceils are required for inflammation and destruction in cigarette smoke-induced emphysema in mice [ J ]. J Immunol, 2007,178 : 8090 - 8096.
10Sharafkhaneh A, Hanania NA, Kim V. Pathogenesis of Emphysema[ J]. Proc Am Thorac Soc ,2008:475 -477.

二级参考文献10

1徐凌,蔡柏蔷,朱元珏,郭子建,张弘,谷丽,徐兴祥.N-乙酰半胱氨酸对大鼠慢性阻塞性肺疾病模型细胞因子和基质金属蛋白酶的影响[J].中华内科杂志,2004,43(8):595-599. 被引量：17
2Cosio M,Ghezzo H,Hogg JC,et al.The relations between structural changes in small airways and pulmonary-function tests.N Engl J Med,1978,298:1277-1281.
3Mitsuyama T,Hidaka K,Furuno T,et al.Release of nitric oxide and expression of constitutive nitric oxide synthase of human endothelial cells:enhancement by a 14-membered ring macrolide.Mol cell Biochem,1998,181:157-161.
4kawakami K,Kadota J,Iida K,et al.Phenotypic characterization of T cells in bronchoalveolar lavag4e fluid(BALF)and peripheral blood of patients with diffuse panbronchiolitis:the importance of cytotoxic T cells.Clin Exp Immunol,1997,107:410-416.
5Santos S, Peinado VI, Ramlrez J, et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. Eur Respir J,2002,19:632-638.
6Peinado VI, Barbera JA, Ramirez J, et al. Endothelial dysfunction in pulmonary arteries of patients with mild COPD. Am J Physiol, 1998,274: L908-L913.
7Cosio M, Chezzo H, Hogg JC, et al. The relations between structural changes in small airways and pulmonary function tests. N Engl J Med, 1978,298 : 1277-1281.
8李红梅,崔德健,佟欣,高亚兵,崔雪梅,王德文.N-乙酰半胱氨酸等对基质金属蛋白酶在大鼠慢性阻塞性肺疾病模型气道细胞外基质重塑中的作用[J].解放军医学杂志,2002,27(7):593-596. 被引量：15
9柴秀娟,骆仙芳,黄卫华,朱婉萍,石玲,黄强,蔡映云.SO_2、木瓜蛋白酶致大鼠肺气肿模型的建立及应用[J].中国中医基础医学杂志,2003,9(6):23-26. 被引量：11
10钟小宁,白晶,施焕中,吴聪,梁国容,冯震博.慢性支气管炎与肺气肿大鼠气道炎症与重塑的实验研究[J].中华结核和呼吸杂志,2003,26(12):750-755. 被引量：54