阿奇霉素缓释阴道栓体外抑菌试验

Study on the Efficiency of Azithromycin Sustained-release Vaginal Suppository in Inhibiting Ureaplasma Urealyticum in Vitro

目的:研究阿奇霉素缓释阴道栓对解脲支原体的体外抑菌效果。方法:采用微量稀释法测定阿奇霉素缓释阴道栓对解脲支原体的最低抑菌浓度,并与阿奇霉素干混悬剂比较。结果:阿奇霉素缓释阴道栓与阿奇霉素干混悬剂对解脲支原体的最低抑菌浓度均小于0.125μg·mL^(-1)。结论:阿奇霉素缓释阴道栓在实验条件下对解脲支原体有显著的抑菌效果。

OBJECTIVE： Study on the efficiency of azithromycin sustained- release vaginal suppository in inhibiting ureaplasma urealyticum（Uu） in vitro.METHODS： The method of microdilution was used to determine the minimal inhibitory concentration（MIC） for Uu that azithromycin sustained- release vaginal suppository campared with azithromycin dried suspension.RESULTS： The MIC for Uu that both azithromycin sustained- release vaginal suppository and azithromycin dried suspension is lower than 0.125μg · mL^-1. CONCLUSION： Azithromycin sustained- release vaginal suppository has significant inhibitive effects on Uu under the experiment condition.