脂溢性角化病的病因与治疗进展

Advances in the etiology and therapy of seborrheic keratoses

脂溢性角化病是一种良性表皮角质形成细胞肿瘤。其病因尚不清楚，可能与遗传因素密切相关，流行病学研究显示年龄和紫外线暴露是本病独立的危险因素，细胞因子及感染可能与其发病有一定的关系。脂溢性角化病的治疗以冷冻、激光为主，但近年来也出现一些新的疗法，如局部外用三氯乙酸，系统应用阿维A等。

Seborrheic keratos-es（SK） is a benign epidermal keratinocyte tumor. The exact etiology of it is still unknown, and likely to be related to genetic factors. Epidemiologic study has revealed that aging and ultraviolet exposure are independent risk factors of this disease. Moreover, cytokines and infection may be associated with the occurrence of it. Cryosurgery and laser evaporation are common therapy for SK. Recently, some new treatment strategies have been developed for it, including topical trichloroacetic acid, systemic acitretin, and so on.