组织蛋白酶在皮肤科的研究进展

Cathepsins in human skin

组织蛋白酶是溶酶体内的蛋白水解酶，与多种器官的纤维化和肿瘤有密切关系。近几年，组织蛋白酶在皮肤科的研究主要集中于：其在正常表皮分化、毛囊形成、皮肤损伤修复及瘢痕形成中的作用；与多种慢性炎症性皮肤病的相关性；对其与皮肤肿瘤发生、转移关系的研究已深入至细胞信号与基因调控，并初涉基因治疗领域。

Cathepsin is a class of intracellular lysosomal proteases and has a close relationship with the fibrosis and tumor development in multiple organs. Recent investigation about cathepsin in dermatology is mainly focused on its role in normal epidermal differentiation, growth of human hair follicles, skin wound repair and skin scarfing, as well as the correlation with different chronic inflammatory dermatoses. To study the relationship of cathepsin to the development and metastasis of skin tumors, relevant cell signals and gene regulation have been investigated, and cathepsin-associated gene therapy is under research.