门静脉收缩器建立犬门静脉高压食管静脉曲张模型的实验研究

Establishment of portal hypertension induced esophageal varices in canine by ameroid constrictor

目的探讨建立稳定的门脉高压食管静脉曲张犬模型的可行性。方法12只杂交犬，采用门静脉．下腔静脉侧侧分流术＋门静脉主干环置ameroid收缩器＋下腔静脉头侧双线交叉缝合结扎的方法制作动物模型。6周后，胃镜和门静脉造影检查观察食管曲张静脉形成情况。结果造模手术前门静脉压力为（11．0±1．1）mmHg，造模后门静脉压力升高至（22．9±1．2）mmHg（P=0．010）。胃镜发现所有的杂交犬均形成了轻-中度食管曲张静脉，门静脉造影检查证实食管中下段有曲张静脉形成，同时腹壁形成了肉眼可见的曲张静脉。结论门静脉收缩器法能成功地建立门脉高压食管静脉曲张动物模型。

Objective To establish the canine model of esophageal varices caused by portal hypertension. Methods The model was established in 12 dogs with a side-to-side portacaval shunt, an ameroid constrictor around the portal vein and double ligation and cross suture of the cephalic part of the inferior vena cava （ IVC）, and the development of esophageal varices was confirmed 6 weeks later by endoscopy and portal vein angiography. Results The mean pre- and postoperative portal pressure were （ 11.0 ± 1. 1 ） mm Hg and （22.9± 1.2） mm Hg, respectively （P = 0. 010）. Endoscopy detected mild to moderate esophageal varices in all dogs, which was confirmed by portal vein angiography, and varices was also seen in abdominal wall. Conclusion Canine model of esophageal varices induced by portal hypertension can be established with the procedure.