新型强脉冲光治疗酒渣鼻的疗效观察

Efficacy of a new intense pulsed light device in the treatment of rosacea

目的观察新型强脉冲光（IPL）治疗酒渣鼻的临床疗效。方法应用IPL治疗仪（Lumenis One^TM，美国科医人公司）治疗85例酒渣鼻患者，其中红斑毛细血管扩张型32例，丘疹脓疱型53例。每3周治疗1次，4次为1疗程。每次治疗前皮损照相以评估治疗效果。测定患者治疗过程中及治疗后6个月皮肤黑素指数、红斑指数、皮脂分泌、角质层含水量的变化情况。结果治疗结束时及治疗后6个月，有效率分别为81．18％和78．82％。治疗结束时，红斑毛细血管扩张型和丘疹脓疱型酒渣鼻有效率分别为75％和84．91％。治疗结束时与治疗前比较，患者面部黑素指数、红斑指数及皮脂分泌显著降低，而角质层含水量无显著变化。随访6个月，各客观评价指标均保持在治疗结束时水平。无患者出现炎症后色素沉着及色素减退。结论新型IPL治疗酒渣鼻疗效显著、副作用小。

Objective To observe the efficacy of intense pulsed light （IPL） incorporated with optimal pulse technology （OPT） in the treatment of rosacea. Methods Thirty-two patients with erythematotelangiectatic rosacea and 53 patients with papulopustular rosacea were treated with IPL-OPT for 4 sessions with an interval of 3 weeks. Patients were assessed clinically and photographically by physicians before each treatment. Skin melanin index, erythema index, sebum secretion level and water content in stratum comeum were tested at the baseline, 3 weeks after each treatment, and 6 months after the last treatment. Results Three weeks after the last treatment, the effective （more than 60% improvement） rate was 81.18% in total, 75% in erythematotelangiectatic rosacea, and 84.91% in papulopustular rosacea; there was no significant difference between erythematotelangiectatic rosacea and papulopustular rosacea （x^2 = 1.28, P 〉 0.05 ）. Six months after the last treatment, the total effective rate still remained at 78.82% with no significant difference from that observed at 3 weeks after the treatment （x^2 = 1.62, P 〉 0.05）. The value of melanin index, erythema index and sebum secretion level decreased significantly after the final treatment, however, water content in stratum corneum remained at the same level as that before treatment. After 6-month follow-up, no significant change was noticed in the above 4 parameters compared with those obtained at 3 weeks after the treatment. Neither hyperpigmentation nor hypopigmentation was observed during the treatment and follow-up. Conclusion This study demonstrates that IPL-OPT is an effective treatment for rosacea with relatively few side effects.