血脂康对心力衰竭患者炎症因子和血管内皮功能的影响被引量：6

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摘要目的观察血脂康短期治疗对胆固醇水平正常的慢性心力衰患者血清肿瘤坏死因子(TNF-α)、白介素-6(IL-6)和肱动脉内皮功能的影响。方法48例慢性心衰患者(NYHA分级Ⅱ～Ⅳ级)随机分成血脂康治疗组(n=24)和对照组(n=24)。2组均遵循慢性心力衰竭治疗指南给予常规治疗,治疗组加用血脂康0.6mg2次/d,共8周。检测治疗前后血清TNF-α、IL-6水平和肱动脉内皮功能。结果血脂康治疗组的血清TNF-α和IL-6水平,在血脂康治疗组明显下降(t=9.09,P<0.01;t=10.09,P<0.01),且与对照组比较差异显著(F=17.13,P<0.01;F=13.32,P<0.05)。肱动脉内皮依赖性血管舒张功能在血脂康治疗组明显提高(t=-5.7,P<0.01),且与对照组比较差异显著(F=13.31,P<0.05)。结论血脂康治疗有助于改善正常胆固醇水平慢性心力衰竭患者内皮依赖性血管舒张功能和抑制炎症过程。

作者彭艳覃数刘剑

机构地区重庆医科大学附属第一医院心血管内科

出处《第三军医大学学报》 CAS CSCD 北大核心 2009年第7期636-638,共3页 Journal of Third Military Medical University

关键词血脂康慢性心力衰竭炎症内皮

分类号 R286 [医药卫生—中药学] R541.605 [医药卫生—心血管疾病]

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