Dysbindin基因在精神分裂症中的研究进展

Advances in the studies of the dysbindin gene in schizophrenia

位于染色体6p22．3区域的Dysbindin基因是精神分裂症的易感基因之一。在大脑中，其功能主要是通过复杂的突触后或前机制影响谷氨酸神经递质的释放，现就Dysbindin基因在精神分裂症中的研究情况进行综述，包括Dysbindin基因及其产物，可能的致病机制，与精神分裂症的关联研究以及该基因变异对精神分裂症患者认知功能可能造成的损害。

Recent reports indicate that the dysbindin gene located on chromosome 6p22.3 is a major susceptibility gene for schizophrenia. In the brain, the dysbindin gene may influence glutamatergic neurotransmission by multiple post- and pre-synaptic mechanisms. This paper reviews the research progress on the dysbindin gene in schizophrenia, including the dysbindin gene and its product, the possible pathogenic mechanisms, the association study of the dysbindin gene with schizophrenia, and the cognitive decline caused by the dysbindin variations.