红曲醋的毒性和降压作用研究

Study on toxicity and hypotensive effect of monascus vinegar

目的:研究红曲醋的亚急性毒性、遗传毒性和对自发性高血压大鼠(SHR)的降压作用。方法:设2.5、5.0、10.0 ml/kg体重3个剂量组,观察红曲醋的亚急性毒性;选择Ames试验、小鼠骨髓细胞微核、精子畸形试验观察红曲醋遗传毒性;设0.5、1.0、3.0 ml/kg体重4个剂量组,同时设阴性对照组(蒸馏水)、溶剂(基醋)对照组和正常大鼠受试样品3.0 ml/kg剂量组,观察红曲醋对SHR的降压作用。结果:各剂量组各项指标均未见有明显的亚急性毒性;各剂量组未见有明显的遗传毒性;红曲醋对正常大鼠无降压作用,对心率无影响;与阴性对照组和溶剂(基醋)对照组比较,SHR第3周3.0 ml/kg剂量组血压、第4周1.0、3.0 ml/kg剂量组血压均有明显下降,差异均有显著性,红曲醋各剂量组对SHR心率无影响。结论:本试验条件下,红曲醋无明显亚急性毒性和遗传毒性;红曲醋具有降血压功能。

Objective：To study the subacute toxicity,genetic toxicity and hypotensive effect of monascus vinegar.Methods：A subacute toxic study in rats was performed by setting 3 different dose groups with 2.5,5.0,10.0 ml/kg.The genetic toxicity of monascus vinegar was observed by Ames test,micronucleus test of bone marrow cells in mice and sperm shape abnormality test in mice.0.5,1.0,3.0 ml/kg dose groups and vinegar control group were setting for observing the hypotensive effect of monascus vinegar for 4 weeks, Systolic blomt pressure（SBP）and heart rate（HR） were measured once a week.Results：There were no obvious subacute toxicity and genetic toxicity in all treated groups.Monascus vinegar has no obvious effect on SBP and HR in normal rats.Compared with the 0 ml/kg and vinegar control group,the SBP of 3.0 ml/kg group at the 3rd week and 1.0,3.0 ml/kg group at the 4th week time were decreased significantly.There were no obvious effect on HR of SHR in all monascus vinegar groups.Conclusion：Under this experimental conditions,it showed that monascus vinegar has no subacute toxicity and genetic toxicity,but also has the hypotensive effect in SHR.