急性呼吸道感染患者1232例非细菌性病原体检测分析

Detection on non-bacterium pathogen in 1232 cases of acute repiratory infection

目的:了解急性呼吸道感染(ARI)的病原体分布情况,为临床诊治ARI提供病原学依据。方法:对ARI患者和健康人的鼻咽分泌物及痰标本用聚合酶链反应技术检测腺病毒(ADV)、巨细胞病毒(CMV)、柯萨奇病毒(COX)、呼吸道合胞病毒(RSV)、肺炎衣原体(CP)、沙眼衣原体(CT)、肺炎支原体(MP)、解脲支原体(UU),分析病原体的分布情况。结果:与健康人比较,ARI患者除CT、UU外其他病原体检测结果的差别均具有统计学意义。在ARI患者中,病原体按阳性率高低的排列顺序为CP(23.7%)>RSV(21.5%)>MP(15.1%)>CMV(13.7%)>COX(12.1%)>ADV(9.8%)>CT(6.8%)>UU(2.3%)。结论:在本地区导致ARI的主要病原体为CP和RSV,MP、CMV、COX、ADV为次要病原体,CT、UU的作用似不重要,但CT在导致小儿ARI中有较重要作用(阳性率13.1%)。

Objective：To analyse the distribution of pathogen of acute respiratory infection（ARI） in order to find out the pathogens basis for treatment of ARI.Methods：Adenovirus（ADV）,Cytomegalovirus（CMV）, Coxsackie virus（COX）,Respiratory syncytial virus（RSV）,Chlamydia pneumonia（CP）,Chlamydia trachomatis（CT）,mycoplama pneumonia（MP） and Ureaplasma urealyticum（UU） were detected by polymerase chain reaction（PCR） in nasopharynx secretion and sputum specimen from 1232 patients with ARI and healthy people.Results：Compare with healthy people,the difference of results had statistical meaning except CT,UU in patients with ARI.The height of positive pathogen were CP（23.7%） 〉 RSV（21.5%） 〉 MP（15.1%） 〉 CMV（13.7%） 〉 COX（12.1%） 〉 ADV（9.8%） 〉 CT（6.8%） 〉 UU（2.3%） in the patients with ARI.Conclusion：CP and RSV are the major pathogens causing the ARI in local area.The secondary pathogens are RSV,MP,CMV,COX and ADV.The effect of UU and CT seem unimportant,but CT takes an important effect on ARI in children（the positive result was 13.1%）.