前列通抗实验性前列腺增生的研究

THERAPEUTIC EFFECT OF QIANLIETONG ON EXPERIMENTAL PROSTATIC HYPERPLASIA

目的：探讨前列通对实验性前列腺增生的治疗作用。方法：利用大鼠和小鼠的前列腺增生模型及兔离体膀胱三角肌标本，观察分析前列通的抗前列腺增生作用和机理。结果：每日给前列通３ｇ／ｋｇ及６ｇ／ｋｇ灌胃，连续３～４周可分别显著抑制丙酸睾丸素引起的大鼠前列腺增生和小鼠尿生殖窦植入性前列腺增生；０．６％及１％前列通水混悬液尚可抑制去甲肾上腺素诱发的兔离体膀胱三角肌收缩作用，抑制率分别达２１％及４６．１％。

Objective:To observe the therapeutic effect of Qianlietong(QLT) on experimental prostatic hyperplasia.Methods:Experimental prostatic hyperplasia was produced in the rat and mouse,and the isolated bladder trigone muscle of the rabbit was used for contraction inhibition study.Results:QLT 3 and 6g/kg that administered intragastrically for 3 and 4 weeks, significantly inhibited the prostatic hyerplasia induced by testosterone propionate in rats, and by transplantation of urinary genitaloid sinus in mice respectively.Otherwise,0.6% and 1% water suspension of QLT also inhibited the contraction induced by norepinephrine in isolated bladder trigone muscle of the rabbit,the inhibition was 21%～46.1%.Conclusion:QLT significantly inhibits epxerimental prostatic hyperplasia,and decreases the contraction of bladder trigone muscle induced by αadrenoceptor agonist.