摘要
目的了解成人呼吸道感染患者急性肺炎衣原体感染的患病情况及临床特征。方法呼吸道感染住院患者110例,同时采集痰和咽拭子标本,应用聚合酶链反应(PCR)检测肺炎衣原体DNA,及采取静脉血检测肺炎衣原体IgG和IgM抗体。结果本组患者肺炎衣原体IgG抗体的阳性率为70%(77/110),其中17例(16%)有肺炎衣原体近期感染的急性抗体,12例(11%)痰和(或)咽拭子肺炎衣原体PCR检测结果阳性,联合应用两种方法的阳性率为23%(25/110)。肺炎衣原体急性感染以支气管哮喘急性发作、肺炎、慢性阻塞性肺疾病急性加重和急性支气管炎患者多见(分别为57%、35%、26%和25%),其临床表现无特征性。结论结果提示成人呼吸道感染患者肺炎衣原体急性感染的阳性率较高,提示肺炎衣原体是呼吸道感染的重要致病原。
Objective To find out the infected rate and the clinical features of patients with acute respiratory infection caused by chlamydia pneumonia(C. pneumoniae) . Method A prospective study for chlamydia pneumoniae infection was conducted in 110 patients with respiratory tract infection from January to December 1995 in Nanjing. Sputum and throat swab specimens were taken and C. pneumoniae DNA were detected by polymerase chain reaction (PCR) with the HM 1 HR 1 primer pair. At the same time, serum samples were taken and immunoglobulins G and M (IgG and IgM) fractions of antibodies to C. pneumoniae were studied by microimmunofluorescence test. Result Prevalence of specific IgG was 70% in patients with respiratory tract infection. Seventeen patients (16%) were serologically diagnosed as having recent C. pneumoniae infection and 12 patients (11%) had the positive PCR in sputum and/or swab specimens. The total positive rate was 23% (25/110) combining PCR with serology. Acute infection of C. pneumoniae was common in the patients with asthma (57%), pneumonia (35%), COPD (26%) and bronchitis (25%). The clinical feature between C. pneumonia infection ( n =5) and non C. pneumonia infecttion ( n =85) was not significanty different. Conclusion Data suggest that Chlamydia pneumonia is an important pathogen that causes infections of the human respiratory tract and attention should be drawn to this special illness.
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
1998年第5期280-283,共4页
Chinese Journal of Tuberculosis and Respiratory Diseases
关键词
呼吸道感染
聚合酶链反应
肺炎衣原体
临床研究
Chlamydia, pneumonia Respiratory tract infection Polymerase chain reaction