^(14)C-尿素呼气试验对胃幽门螺杆菌感染的诊断价值

Diagnostic value of 14 C urea breath test for Hp associated peptic ulcer

目的建立１４Ｃ尿素呼气试验，评价其临床应用价值。方法胃镜下取胃窦粘膜作细胞培养及病理切片，染色阳性为幽门螺杆菌（Ｈｐ）感染的对比指标。对１３８４例临床怀疑为胃及十二指肠疾病的患者进行呼气试验，其中４４例行多时相动态呼气试验，以确定最佳集气时间。结果动态检测示３０分钟为１４Ｃ呼气量峰值，如将Ｈｐ阳性阈值定于呼气比值大于３５，则１４Ｃ呼气试验对Ｈｐ感染检出的灵敏度为９６７％，特异性为９６５％。１４Ｃ呼气试验在成人人群中的阳性率为５０４％，在儿童中为８１２％。结论１４Ｃ呼气试验在胃肠道Ｈｐ感染检测中具有良好的灵敏度及特异性，方法简便可靠。

Purpose To develop a method of 14 C urea breath test and to evaluate the accuracy of the method in clinical diagnosis Methods Helicobacter pylori(Hp) positive patients were defined either by positive bacterial culture or by positive rapid urease test of endoscopic biopsy specimens 1384 patients with suspected peptic disease were underwent 14 C urea breath test Of them, 44 patients underwent dynamic test at various intervals to determine the optimal time for expiratory air collection Results Dynamic breath test showed that the highest point of 14 C counts was at 30min after administration of 14 [KG*3/5]C urea When a cut off value of 3 5 was selected, the sensitivity and specificity was of the test for detecting Hp infection 96 7% and 96 5% respectively Hp positive rate detected by 14 C urea breath test in 1092 adults and 292 children was 50 4% and 81 2% Conclusions This study suggests that 14 C urea breath test is a simple and reliable method for detection of Hp infection and is of high sensitivity and specificity