放射性核素心脏显像对SLE患者的临床应用

Evaluation of cardiac function in SLE using radionuclide ventriculography

目的评价系统性红斑狼疮（ＳＬＥ）患者左心室功能。方法用平衡法门电路心室显像及心肌显像测定２０例正常人和３０例ＳＬＥ患者左室收缩和舒张功能。结果ＳＬＥ患者左室射血分数、相角程、高峰射血率、高峰充盈率分别为０５２±０１１、６０８９±１２１２°、３０８±０４８ＥＤＶ／ｓ和２８８±０４７ＥＤＶ／ｓ；正常对照组分别为０６８±００２、５３２５±５２６°、３６６±０５１ＥＤＶ／ｓ和３３４±０８８ＥＤＶ／ｓ。两组比较，ｔ值分别为４５０、３１１、５８０和４６０，Ｐ均＜００１。阳性率为４８６％，心肌显像阳性率为６４％；放射性核素心脏显像检测ＳＬＥ心肌损害的灵敏度为６３％，特异性为８５％。结论放射性核素心脏显像可以客观评价ＳＬＥ患者左心室功能，对发现ＳＬＥ心肌损害及指导治疗有一定意义。

Purpose To evaluate the left ventricular function of systemic lupus erythematosus (SLE) patients by equilibrium radionuclide ventriculography Methods 20 normal controls and 30 SLE patients were studied by gated cardiac blood pool imaging and gated myocardial imaging and the left ventricular systolic and diastolic parameters were analysed Results The LVEF, SH, PER and PFR of 30 SLE patients were 0 52±0 11, 60 89±12 12°, 3 08±0 48EDV/s and 2 88±0 47EDV/s While those parameters of 20 normal controls were 0 68±0 02, 53 25±5 26°, 3 66±0 51EDV/s and 3 34±0 88EDV/s, respectively The parameters of sistolic and diastolic function were significantly lower in patients than those in controls (t=4 50, 3 11, 5 80 and 4 60, P<0 01) Conclusions The cardiac function of SLE patients was lower (poorer) as compared with that of normal population Radionuclide ventriculography is useful to evaluating cardiac function in SLE patients and thereby helps with the diagnosis of the myocardial damage in the disease and guides the treatment of it