摘要
目的探讨血铅水平与神经细胞损伤的关系。方法用电镜硝酸镧示踪法，钙细胞化学定位法和Ｇｏｌｇｉ染色法，观察从断奶第一天起，饮用了３个月Ｐｂ２＋水（分别为１０和３０ｍｇ／Ｌ）的幼鼠脑组织。结果低剂量组血铅浓度为对照组的１６７倍时，所观察的指标无明显改变。高剂量组血铅浓度为对照组的２４６倍时，可见神经细胞渗透性改变和Ｃａ２＋在质膜内的分布增加，同时部分神经细胞树突与轴突内微管解聚，轴突弯曲，树突远端直径变小和树突侧棘数减少。
Objective To study the relationship between blood lead levels and damage in neurone cells. Methods Young rats were fed with water containing 10 and 20 mg/L of lead for three months since the first day of their weaning. Lanthanum nitrate tracing, calcium cytochemical location technique and Golgi's stain were used to observe changes in rat brain tissues. Results There were no obvious changes in brain tissues of the low dose group as its blood lead level reached 1.67 times high as that in control one. Permeability of neurone cells changed and distribution of calcium in plasmalemma increased and their cytoplasm disintegrated in part of the microtubule in the dendrites and axons of the neurones as its blood lead level in high dose group reached 2.46 times high as that in control one. Conclusion It is possible that pathological changes found in this study provide a basis for the decrease in cognitive function caused by lead during their middle brain development in rats.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1998年第3期150-152,共3页
Chinese Journal of Preventive Medicine
基金
卫生部招标课题
