肺炎患儿TNFα、G-CSF和sIL-2R检测及临床意义

The Determination of TNFα,G-CSF and slL-2R in Children with Pneumonia and Their Clinical Significance

测定170例肺炎患儿肿瘤坏死因子(TNFα),粒细胞集落刺激因子(G-CSF)和可溶性白介素2受体(sIL-2R)的含量。结果显示:(1)TNFα含量细菌肺炎组为(0.398±0.078)μg/L,比非细菌感染组升高明显(P<0.05)。2.G-CSF的阳性率和阳性指数(PI)细菌肺炎组分别为87.08％和10.96±3.85,比非细菌肺炎组显著升高(均P<0.01);(3)sIL-2R含量肺炎组为(531.67±148.26)kU/L与对照组差异显著(均P<0.01),随病情加重其含量明显增高(P<0.05)。实验表明:肺炎患儿免疫功能紊乱和病情加重与sIL-2R和TNFα明显增高有关;而TNFα和G-CSF的变化对阐明炎症发病机制以及初步鉴别细菌感染与病毒和支原体感染有重要临床意义。

The levels of TNFα,G-CSF and sIL-2R were determined in 170 children with pneumonia. The results showed:(1)The levels of TNFa in bacterial pneumonia were(0.398±0.078)ng/ml,obviously increased than non-bacterial infection group(P<0.05). (2) The positive rate and positive index (PI) of G-CSF in bacterial pneumonia were 87.08% and 10.96±3.85 respectively,there were marked difference between bacterial and non-bacterial infections (P<0.01). (3) The sIL-2R levels of pneumonia patients were (531.67± 148.26)kU/L, and there was significant difference(P < 0.01). sIL-2R levels were increaed markedly when the state of illness became worse( P < 0.05). All above shows: the disorder in immunity of children with pneumonia and the state of illness were related with the increase of sIL-2R and TNFα the changes of TNFα and G-CSF level may indicate an inflammatory pathogenetic mechanism, and have important clinical significance in distinguishing between bacterial, viral and mycoplasma infections.