保乳术中放射性粒子插植放疗31例临床观察

The Early Results of Breast-conserving Therapy with 125I in 31 Patients of Primary Breast Cancer

目的研究放射性碘125（^125I）粒子保乳术中插植治疗早期乳腺癌的新方法及临床意义。方法肿物局部扩大切除到切缘病检阴性。根据瘤区残留的大小计算出^125I粒子的粒数，依TPS绘制粒予布入计划图，按图插植布入粒子。结果本组31例切口100％I期甲级愈合：随访12-38个月，无局部复发，无淋巴结及远位器官转移，无不良反应。结论近距离放射性粒子插植与保乳治疗早期乳腺癌是乳腺癌治疗新兴手段之一，其安全有效，对于降低局部复发率，改善患者生活质量具有一定的意义，但应进行更深入的研究。

Objective To discuss the effects of breast-conserving therapy with 1251 in early primary breast carcinoma. Methods 31 patients with stage I to II primary breast cancer were operated with wide local excision and axillary lymph node dissection. In operation, the radiation therapy was done with^125I .Results Breast conservation surgery was taken successfully in 31 patients. After operation, the wound recover rate for their breast were Satisfactory. After a median follow-up of 12-38 months, there were no cases of local relapse , distant relapse and death. Conclusions The early results of breast-conserving therapy with ^125I are satisfactory for stage I to II primary breast cancer. The long-term follow-up is needed for the final outcome.