临床评价氨茶碱血药浓度及给药方案预测系统

PROGRAMME FOR AMINOPHYLLINE STEADY-STATE CONCENTRATION PREDICATION AND DOSAGE ADJUSTMENT

通过实测119例口服氨茶碱病人稳态后2、4、6、8h血药浓度，并与预测浓度及Bayesian法预估浓度对比，评价文献报道的氨茶碱血药浓度及个体给药方案预测系统（ACWS）的准确性和可靠性。结果各时间预测浓度与实测浓度相关系数为0.9660～0.9987；误差范围：2h在0.01～3．29μg／ml，6h在0．01～1．89μg／ml，8h在0．02～1.98μg／ml。6例支气管哮喘病人ACWS预测浓度比Bayesian法预估浓度误差均值小。

Routine clinical pharmacokinetic data collected from 119 patients orally receiving aminophylline have been analysed to propose a new and simple programme (ACWS) to aid the dosage ad justment of this drug. The steady-state concentrations of theophylline at 2, 4, 6, 8h postdose were measured and compared with that estimated either by the Bayesian method or by ACWS. The results showed that the correlation coefficients of concentrations measured and estimated at different time were in the range of 0.9660-0.9987. The predication c6ncentration errors at 2, 6, 8h postdose were 0.01-3. 29μg/ml, 0.01-1.89μg/ml, 0. 02-1. 98μg/m1. Using the proposed method,the mean variability.of predicated concentration of six bronchial asthma patients was lower than that estimated with the Bayesian method.