摘要
目的:观察刺激迷走神经对红藻氨酸诱发癫痫大鼠海马内c-fos表达的变化.探讨此方法抑制癫痫的机制及可能途径.方法:用免疫细胞化学技术观察红藻氨酸致痫及刺激迷走神经后1h大鼠海马及其它脑区c-fos表达的变化.结果;腹腔注射红藻氨酸后1h,海马内有大量Fos标记细胞;单纯刺激迷走神经在孤束核、外侧缰核可见大量Fos标记细胞;刺激迷走神经后再给予红藻氨酸,海马内Fos标记细胞的数量明显减少.结论:刺激迷走神经可抑制癫痫大鼠海马c-fos表达,在这一过程中存在着一定的功能通路.
To observe the inhibitic effects of vagus nerve stimulation on c-fos expression in hippocampus of rat with epilepsis induced by kainate. Methods:The variation of c-fo,s expression in hippocampus and other brain areas of epilepsis rats 1 h after bainale injection was observed by im-munocytochemistry. and compared it with those pretreated with vague nerve stimulation immunohistochemistry. Results: One hour after kainate injection, a large number of Fos-labeled neurons were observed in hippocampus; vagus nerve stimulation alone induced a strong expression of c-fis in solitary nucleus and lateral habenular nucleus; after stimulation followed by injection of kainate, the number of Fos-labeled neurons was significantly reduced. Conclusion: Vagus nerve stimulation can inhibit c-fos expression in epileptic rat hippocampus. There are specific functional pathways existing in the control of seizures.
出处
《第四军医大学学报》
1998年第2期189-191,共3页
Journal of the Fourth Military Medical University
