摘要
目的探讨氯喹对烟雾吸入伤大鼠肺微血管通透性的影响。方法健康Wistar大鼠随机分成正常对照组,吸入伤1,3,5,12,24h组及氯喹治疗6h和12h组。肺含水量用干湿重法测定,肺微血管通透性用131I-白蛋白渗出量表示,肺出血量用99Tc标记的红细胞出量表示。结果烟雾吸入伤后肺水含量、131I-白蛋白渗出量明显增加,至伤后6h达峰值(P<0.01),而肺内99Tc红细胞出量以伤后1h最明显,伤后24h仍明显高于正常对照组(P<0.01),氯喹治疗伤后6h组,上述指标明显低于吸入伤6h组(P<0.01)。结论氯喹可以明显降低烟雾吸入伤大鼠肺微血管通透性。
AIM To explore the effect of chlorqurine on pulmonary microvascular permeability in rats after smoke inhalation injury. METHODS Wistar rats were randomly divided into control group, injured groups following smoke inhalation 1, 3, 6, 12, 24 h and treated groups with chlorqurine (10 mg·kg-1, immediately injection intraperitoneally after smoke inhalation) following smoke inhalation 6, 12 h, the content of lung water was measured with drywet weight, the pulmonary microvascular permeability was represented by 131Ilabelled albunim exudation, pulmonary hemorrhage was quantitated with 99mTclabelled erythocytes. RESULTS There were significant increases in the content of lung water and the exudation of 131Ilabelled albumin and reached peak level of 6 hour after smoke inhalation injury (P<001), the countered numbers of 99mTclabelled erythocytes was the highest at 1 hour following smoke inhalation and was higher at 24 hours after smoke inhalation compared with control group; there were obvious decreases in the content of lung water, the exudation of 131Ilabelled albumin and the countered numbers of 99mTclabelled erythocytes in chlorqurine treatment group at 6 hours following smoke inhalation compared with injoured group at 6 hours after smoke inhalation (P<001). CONCLUSION Chlorqurine might decreased the pulmonary microvascular permeability of rats after smoke inhalation injury.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1998年第2期115-117,共3页
Chinese Pharmacological Bulletin
基金
全军"九五"指令性课题
关键词
肺
微血管通透性
氯喹
烟雾吸入伤
lung
microvascular permeability
pulmonary hemorrhage
chlorqurine
smoke inhalation injury
rat