自然流产患者的免疫因素分析

Analysis on immunological factors of spontaneous abortion

目的:探讨自然流产与免疫因素的关系。方法:采用酶联免疫吸附试验(ELISA)对456例自然流产妇女(流产组)进行血清抗精子抗体(ASAb)、抗卵巢抗体(AOAb)、抗子宫内膜抗体(EMAb)及抗绒毛膜促性腺激素抗体(HCGAb)的检测;选择正常妊娠妇女86例作为对照组。结果:流产组的ASAb、AOAb、EMAb和HCGAb的阳性率分别为28.1%、25.2%、26.1%和23.0%,明显高于正常对照组的5.8%、1.2%、1.2%和3.5%,两组比较差异有高度显著性(P均<0.001)。4种抗体联合检测,抗体的阳性率为42.1%,与单独检测ASAb、HCGAb、AOAb和EMAb相比,差异均有高度显著性(P<0.001)。结论:免疫因素是自然流产的不容忽视的因素,4种抗体的联合检测较单一抗体检测阳性率高,对自然流产的临床诊治有指导意义。

Objective： To explore the relationship between spontaneous abortion and immunological factors. Methods： The levels of serum antisperm antibody （ASAb） , antiovarian antibody （AOAb） , endometrial antibody （EMAb） and ehorionic gonadotrapin antibody （HCGAb） in 456 women with spontaneous abortion （abortion group） and 86 healthy women （control group） were detected by ELISA. Results： The positive rates of ASAb, AOAb, EMAb and HCGAb in abortion group were 28. 1% , 25.2% , 26. 1% and 23.0%, respectively, while 5.8% , 1.2% , 1.2% and 3.5% in control group, there was significant difference between two groups （P 〈 0. 001 ）.The positive rate of joint detection of 4 antibodies was 42. 1%. There was significant difference in positive rate between joint detection and single antibody detection （P 〈 0. 001 ） . Conclusion： Spontaneous abortion is mainly related to immunological factors. Positive rate of joint detection of 4 antibodies is higher than that of single antibody detection, which plays an important role in the prophylaxis and treatment of spontaneous abortion.