芸香甙的药代动力学研究

Study on pharmacokinetics of rutoside

目的研究芸香甙在兔体内的药代动力学。方法家兔一次静注芸香甙５ｍｇ·ｋｇ－１后，利用荧光分光光度法测定不同时间的血药浓度。应用３Ｐ８７药动学软件程序对数据进行计算机处理。结果芸香甙的药时（Ｃ－Ｔ）方程为：Ｃ＝８５．９７８９ｅ－０．９０４４Ｔ＋３４．５１０５ｅ－０．０５８７Ｔ＋４．３８３８ｅ－０．００４６Ｔ。芸香甙的主要药代动力学参数如下：Ｔ１／２ａ：（０．７６０９±０．１０６６）ｍｉｎ，Ｔ１／２ｂ：（１２．５６６７±３．７１３９）ｍｉｎ，Ｔ１／２ｃ：（１６２．５６５１±５０．６０３５）ｍｉｎ，Ｋ１２：（０．５１２３±０．１３１６）ｍｉｎ－１，Ｋ２１：（０．３２９８±０．０７３７）ｍｉｎ－１，Ｋ１３：（０．０７３９±０．０１８２）ｍｉｎ－１，Ｋ３１：（０．０１００±０．００３７）ｍｉｎ－１，Ｋ１０：（０．０７７４±０．０１６０）ｍｉｎ－１，Ｖｃ：（０．０４０４±０．００４４）Ｌ·ｋｇ－１，ＡＵＣ：（１６７９．７５８３±４８０．６０４５）ｍｇ·Ｌ－１·ｍｉｎ－１，ＣＬ（ｓ）：（０．００３１±０．０００８）Ｌ·ｋｇ－１·ｍｉｎ－１。结论芸香甙在兔体内的Ｃ－Ｔ变化符合三室开放模型；芸香甙在体内的分布、消除迅速。

AIM To study the pharmacokinetics of rutoside in rabbits. METHODS After administration of rutoside (5 mg·kg-1, iv), the plasma concentration at different times were determined by fluorescence spectrophotometry. The data were proccssed with 3P87 pharmacokinetic procedure. RESULTS The concentrationtime (CT) equation is: C=859789 e-0.9044 T+345105 e-0.0587 T+43838 e-0.0046 T. The pharmacokinetic parameters are as follows: T1/2a:(07609±01066) min,T1/2b:(125667±37139) min,T1/2c:(1625651±506035) min,K12:(05123±01316) min-1,K21:(03298±00737) min-1,K13:(00739±00182) min-1,K31:(00100±00037) min-1,K10:(00774±00160) min-1, Vc:(00404±00044) L·kg-1,AUC:(16797583±4806045) mg·L-1·min,CLs:(00031±00008) L·kg-1·min-1. CONCLUSION In the body of rabbit, the CT change of rutoside conforms to an open three compartment model, the distribution and the elimination of rutoside are rapid.