P16蛋白在肺癌中的表达及其临床意义

P16 expression in lung cancer and its significance

目的探讨抑癌基因ｐ１６与肺癌预后的关系。方法应用ＳＰ免疫组织化学方法对７６例肺癌标本中ＣＤＫＮ２抑癌基因Ｐ１６蛋白表达进行了研究。结果７６例肺癌标本中Ｐ１６蛋白表达阳性率为４５％（３４／７６）。其中鳞癌的阳性率为５２％（２３／４４），腺癌为２９％（７／２４），二者比较差异有显著意义（Ｐ＜０．０５）。Ｐ１６蛋白表达与肺癌的病理分级及预后呈显著相关性（Ｐ＜０．０５）。结论ｐ１６基因对肺癌的发生发展有着重要意义。

Objective To study the relationship of suppressor gene p16 and lung cancer for prognosis evaluation. Methods Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin fixed, paraffin embedded tissue specimens of human lung cancer. Results P16 positive rate was 45%: 52% for 23 of 44 cases of squamous carcinoma and 29% for 7 of 24 cases of adenocarcinoma. Differentiation degree and prognosis of lung cancer were associated significantly with P16 expression. P16 expression was somewhat related to clinical stage. Conclusion p16 gene plays a key role in the prognosis of patients with lung cancer.