摘要
目的探讨不稳定型心绞痛(UAP)患者不同危险分层血清心脏型脂肪酸结合蛋白(H-FABP)的水平及临床意义。方法分别测定稳定型心绞痛(SAP)患者20例(SAP组)、UAP患者55例(UAP组)、健康体检者30例(对照组)的血清H-FABP水平,并根据危险分层将UAP组分为低危组、中危组、高危组三个亚组。结果对照组血清H-FABP水平为(4.24±1.40)ng/ml,SAP组为(4.46±1.30)ng/ml,UAP组为(6.05±1.57)ng/ml;UAP低危组、中危组、高危组分别为(4.82±1.18)、(5.96±1.01)、(7.51±1.11)ng/ml。UAP低危组、SAP组、对照组血清H-FABP水平两两比较均无统计学差异(P均>0.05);UAP组与对照组、SAP组比较均有统计学差异(P均<0.01);UAP低危组、中危组、高危组两两比较均有统计学差异(P均<0.01)。结论血清H-FABP水平随UAP危险程度增加而升高,可根据H-FABP水平对UAP患者进行危险分层。
Objective To determine the value of heart-type fatty acid-binding protein (H-FABP) in risk stratification of patients with unstable angina pectoris. Methods Serum H-FABP levels were measured in 105 subjects who were divided into three groups: stable angina pectoris group (SAP), 20 patients; unstable angina pectoris group (UAP), 55 patients; and normal control group, 30 subjects. Results Serum H-FABP levels of unstable angina pectoris, stable angina pectoris group and normal control group were (4.82 ± 1.18 ), (4.46 ± 1.30 ) and (4. 24 ± 1.40 ) ng/ml respectively, and there were not statistically significant among those three groups. Serum H-FABP levels were significantly higher in unstable angina pectoris group than in normal control group [ (6.05 ± 1.57) ng/ml vs (4.24 ± 1.40) ng/ml, P 〈0.01 ]. According to the risk stratification of unstable angina pectoris patients, serum H-FABP levels in high-risk subgroup were the highest among low-risk, middle-risk and high-risk subgroup ( P 〈 0.01 ) ; serum H-FABP levels were significantly higher in middle-risk patients than in low-risk patients ( P 〈 0.01 ). Conclusions Elevation of H-FABP is associated with an high-risk stratification of unstable angina pectoris patients. High serum H-FABP levels may represent latent cardiac injury.
出处
《山东医药》
CAS
北大核心
2009年第9期1-2,共2页
Shandong Medical Journal
基金
贵州省优秀科技教育人才省长专项基金项目(黔省专合字2008-88)
关键词
心脏型脂肪酸结合蛋白
心绞痛
不稳定型
危险分层
heart-type fatty acid-binding protein
angina pectoris, unstable
risk stratification