钯碳催化的酮与伯醇的α-烷基化反应

Pd/C-catalyzed α-Alkylation of Ketone with Primary Alcohol

以环己烯为活性氢接受体，1，4-二氧六环为溶剂，在Pd／C催化下酮可以有效地与伯醇进行α-烷基化反应生成偶联酮，产率43％～78％，其结构经^1H NMR，IR和MS表征。提出了可能的催化反应机理。

Coupled ketones in yield of 43% -78% were synthesized by α-alkylation of ketones with primary alcohols using Pd/C as a catalyst and cyclohexene as a hydrogen acceptor in dioxane. The structures were confirmed by ^1H NMR, IR and MS. The possible reaction mechanism was suggested.