期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

末端N-Ivdde保护的氨基酸的合成 被引量：1

Synthesis of End N-Ivdde Protected Amino Acid
下载PDF
导出
摘要 以Ivdde为保护基,对4种氨基酸(Fmoc-Dap-OH,Fmoc-Dab-OH,Fmoc-Orn-OH和Fmoc-Lys-OH)的末端氨基进行保护,分别合成了末端氨基Ivdde保护的氨基酸[Fmoc-Dap(Ivdde)-OH,Fmoc-Dab(Ivdde)-OH,Fmoc-Orn(Ivdde)-OH和Fmoc-Lys(Ivdde)-OH],其结构经1HNMR,13C NMR,IR及元素分析表征。 Four kinds of N-Ivdde protected amino acid [ Fmoc-Dap （Ivdde） -OH, Fmoc-Dab （Ivdde） - OH, Fmoc-Orn（Ivdde）-OH and Fmoc-Lys（Ivdde）-OH] were synthesized by protecting the end amido of amino acid（Fmoc-Dap-OH, Fmoc-Dab-OH, Fmoc-Orn-OH and Fmoc-Lys-OH） using Ivdde as a protecting group. The structures were confirmed by ^1H NMR,^ 13C NMR, IR and elemental analysis.
作者 李文曲 徐红岩 李战雄
机构地区 苏州大学纺织与服装工程学院 中国科学院上海有机化学研究所
出处 《合成化学》 CAS CSCD 北大核心 2009年第2期213-215,共3页 Chinese Journal of Synthetic Chemistry
关键词 氨基酸 保护基 Ivdde 合成 amino acid Ivdde protected group synthesis
分类号 O629.71 [理学—有机化学]
  • 相关文献

参考文献6

  • 1Bloomberg G B, Askin G, Gargaro A R, et al. Synthesis of a branched cyclic peptide using a strategy employing Fmoc chemistry and two additional orthogonal protecting groups [ J ]. Tetrahedron Letters, 1993,34 : 4709 -4712.
  • 2Truffert J C, Lorthioir O, Asseline U, et al. On-line solid phase synthesis of oligonucleotide-peptide hybrids using silica supports [ J ]. Tetrahedron Letters, 1994, 35:2353 - 2356.
  • 3Ahlborg N J lmmunol. Synthesis of a diepitope multiple antigen peptide containing sequences from two malaria antigens using Fmoc chemistry [ J ]. Methods, 1995,179:269 - 275.
  • 4Bycroft B W, Chan W C, Hone N D, et al. Synthesis of the spider toxins nephilatoxin-9 and -11 by a novel solid-phase strategy [ J ]. Journal of the American Chemical Soeiety,1994,116:7415 -7416.
  • 5Nash I A, Bycroft B W, Chan W C. Ddc-A selective primary amine protecting group: A facile solid phase synthetic approach to polyamine conjugates [ J ]. Tetrahedron Letters, 1996,37:2625 - 2628.
  • 6Keilam B, Bycroft B W, Chhabra S R. Solid phase applications of Dde and the analogue Nde:Synthesis of trypanothione disulphide [J]. Tetrahedron Letters, 1997,38:4849 - 4852.

同被引文献26

  • 1Prasad S R. Preparation of amino-protected lysine derivatives[ P]. US0042536. 2002 -4 - 11.
  • 2Barrie Kellam, Barrie W B, Weng C, et al . Solid phase strategies : Applications of 2-acetyl-4-nitroindane-1,3-dione as a selective protecting group for primary amines [ J]. Tetrahedron Lett, 1998,54:6817 - 6832.
  • 3Barbara Rohwedder, Yvan Mutti. Hydrazinolysis of Dde Complete orthogonality with Aloc protecting groups [ J ]. Tetrahedron, 1998,39 : 1175 - 1178.
  • 4Diaz-Mochon J J, Bialy L, Bradley M . Full Orthogonality between Dde and Fmoc:The Direct Synthesis of PNA- Peptide Conjugates [J]. Org Lett,2004,6 (7): 1127 - 112 9.
  • 5Srinivasan A, Wilhelm R R,Michelle A S . Intramolecular migration of the β-Dde protecting group of diaminopropionyl to the a-position during Fmoc solid phase synthesis[ C ] // Peptide : Frontier of peptide science : Proceeding Of Fifteenth American Peptide Symposium. Netherlands : Kluwer Academic Publishers, 1998:269 - 270.
  • 6Bloomberg G B, Askin D, Gargaro A R, et al . Synthesis of a branched cyclic peptide using a strategy employing Fmoc chemistry and two additional orthogonal protecting groups [ J ]. Tetrahedron Lett, 1993,34 (29) :4709 - 4712.
  • 7Merrifield R B. Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide [ J ]. J Am Chem Soc, 1963,85 (14) :2149 - 2154.
  • 8Norbert Sewald, Hans-Dieter Jakubke . Peptides : Chemistry and Biology[ M]. Germany: Wiley-VCH Verlag Publ, 2002 : 135 - 256.
  • 9Nathalie Thieriet, Jordi Alsina, Ernest Giralt, et al . Use of Alloc-amino Acids in Solid-Phase Peptide Synthesis. Tandem Deprotection-Coupling Reactions Using Neutral Conditions[ J ]. Tetrahedron Lett, 1997,38 ( 41 ) : 7275 - 7278.
  • 10Nash I A, Bycroft B W,Chan W C. Dde-A selective primary amine protecting group:A facile solid phase synthetic approach to polyamine conjugates [ J ]. Tetrahedron Lett, 1996,37 ( 15 ) :2625 - 2628.

引证文献1

二级引证文献2

合成化学
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部