2-氯烟酸的合成

Synthesis of 2-Chloronicotinic Acid

以3-氰基吡啶(2)为原料,经氧化、氯化和水解反应合成了2-氯烟酸(1),总收率75.1%,其结构经IR和MS表征。最点考察了影响氧化反应的因素,最佳氧化反应条件为:2410 mmol,n(H2O2)∶n(2)=1.2∶1.0,在钨酸盐催化下于70℃反应8 h,收率92.2%。

2-Chloronicotinic acid（1 ） in total yield of 75.1% was synthesized from 3-cyanopyridine （2） by the reaction of oxidation, chlorination and hydrolysis. The structure was identified by IR and MS. The appropriate oxidation conditions in yield of 92.2% at 70 ℃ for 8 h were as follows： 2 was 410 retool; n（H2O2） ：n（2） was 1.2：1.0.