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热休克蛋白27及Bcl-2在宫颈鳞癌中的表达及意义 被引量:2

Expression and Significance of HSP27 and Bcl-2 in Cervical Squamous Cell Carcinoma
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摘要 目的探讨热休克蛋白27和Bcl-2在宫颈鳞癌中的表达及意义。方法应用免疫组化方法检测HSP27、Bcl-2在7例正常宫颈组织,18例宫颈上皮内瘤变,60例宫颈鳞癌中的表达。结果宫颈鳞癌组织中HSP27、Bcl-2阳性表达率显著高于正常宫颈组织(P<0.05);宫颈鳞癌中HSP27的阳性表达与病理分级密切相关(P<0.05);HSP27与Bcl-2在宫颈鳞癌中的表达无明显一致性(P>0.05)。结论HSP27、Bcl-2均在宫颈鳞癌发生和发展中起重要作用;HSP27可能参与了宫颈鳞癌的早期发生。 Objective To explore the expression and significance of HSP27 and Bcl-2 in cervical squamous cell carcinoma. Methods Immunohistochemical method for HSP27 and Bel-2 were performed on 60 cases of cervical squamous carcinomas, 18 cases of CIN and 10 cases of normal cervical tissues. Results In cervical squamous cell carcinoma, the expressions of HSP27 and Bcl-2 were markedly higher than those of normal cervical samples, HSP27 expression was closely correlated with the pathological grade ; there were no relations between the expression of Bcl-2 and HSP27. Conclusion HSP27 and Bcl-2 should play an important role in the genesis and development of cervical squamous cell carcinoma.
出处 《河南科技大学学报(医学版)》 2009年第1期14-16,共3页 Journal of Henan University of Science & Technology:Medical Science
关键词 宫颈癌 热休克蛋白27 白血病基因-2 cervical carcinoma heat shock protein27 Bcl-2
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