摘要
目的优化石杉碱甲骨架片的处方。方法以石杉碱甲骨架片的硬度、体外累积释放度为指标,采用3因素3水平正交设计法优化石杉碱甲骨架片的处方。结果优化所得处方HPMCK15M用量为48%,PVPP用量为6%,CMCNa用量为10%,硬度范围合适,体外溶出度符合缓释制剂要求。结论该优化所得的石杉碱甲骨架片处方可行,合理稳定。
Objective To optimize the formulation of Huperzine -A matrix tablets （HA-MT） . Methods According to the orthogonal design method with 3 factors and 3 levels, the formulation was optimized using hardness and cumulative release as evaluation parameters. Results The optimum formula was as follows： HPMCK15M （48%）, PVPP （6%）, CMCNa （10 %）. The hardness was proper and the cumulative release fulfilled the requirement of sustained-release dosage form design. Conclusion The formulation of matrix tablets is feasible and stable.
出处
《中南药学》
CAS
2009年第3期174-176,共3页
Central South Pharmacy
关键词
正交试验
石杉碱甲
骨架片
缓释制剂
orthogonal design
Huperzine-A
matrix-tablet
sustained-release
