氯氮平引起意识障碍的调查分析

Investigation and analysis of conscious disturbance induced by clozapine

目的:研究探讨氯氮平导致意识障碍的机制以便更安全合理地应用于临床。方法:对500例服用氯丙嗪和500例服用氯氮平的精神分裂症患者中出现意识障碍的人数进行统计比较。结果:在首次应用或调整用药量或在停用后再次服用的过程中,氯氮平更易导致意识障碍。结论:氯氮平易导致意识障碍,不宜作为精神分裂症治疗的首选药物。

Objective： To investigate the mechanism of conscious disturbance by clozapine and discuss how to make good clinic use of clozapine. Method： Five hundred patients taking clozapine and ehloropromazine were observed and compared to the inddence d conscious disturbance. Results： Incidence of conscious disturbance by clozapine were higher than those by chloropromazine at the lust administration, adjusted administration and re-administration. Conclusion： Clozapine can cause conscious disturbance more easily and make serious complications. It＇s not suitable to be chosen for schizophrenia first.